This trial is trying to help people with the most common type of pancreatic cancer. This cancer is usually treated with two chemotherapy drugs given together. Now, doctors and cancer scientists want to find out if adding a third drug can make the treatment work better.
The immune system is important for fighting cancer, but with pancreatic cancer, special cells called macrophages make it harder for the immune system to do its job. These macrophages have a tiny part on their surface called CCR1. CCR1 sends signals that make the macrophages work harder to block the immune system.
In the lab, scientists tested this in mice with pancreatic cancer. They gave the mice a drug to block CCR1 called VP-002, and it slowed down the macrophages. This allowed the immune system to work better and helped the chemotherapy drugs fight the cancer.
This trial is testing if the same three-drug combination can help people with pancreatic cancer. The researchers hope that blocking CCR1 will make it easier for the immune system and chemotherapy to work together in humans.
